If you are using AMP for Endpoints in your lab or implementation, I would highly recommend adding the cloud connection to your Firepower Management Center. The reason you would do this is that it allows you to import threat identifications, indications of compromise (IOC), and other malware-related information that the AMP cloud gathers from the endpoints.
In this post, I'm going to go through the configuration of Firepower v6.0.x for pxGrid integration with ISE using CA-signed certificates. In future posts, I'm planning on going through the configuration for both Firepower 5.4 and 6.0 using both self-signed and CA-signed certificates. The reason I plan on doing that is because they are slightly different and it's important to know this.
In this post, I'm going to do a basic setup of my ASA with Firepower. I'm not going to dig too deep into individual policies since those should be dedicated to their own blog post. Instead, I'm going to go through the basic setup of the ASA and the Firepower Management Center (FMC).